Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination
نویسندگان
چکیده
منابع مشابه
The histone methyltransferase MMSET regulates class switch recombination.
Wolf-Hirschhorn syndrome (WHS) is a genetic disease with characteristic facial features and developmental disorders. Of interest, loss of the MMSET gene (also known as WHSC1) is considered to be responsible for the core phenotypes of this disease. Patients with WHS also display Ab deficiency, although the underlying cause of this deficiency is unclear. Recent studies suggest that the histone me...
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متن کاملHistone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination.
In B cells, Ig class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), the activity of which leads to DNA double-strand breaks (DSBs) within IgH switch (S) regions. Preferential targeting of AID-mediated DSBs to S sequences is critical for allowing diversification of antibody functions, while minimizing potential off-target oncogenic events. Here, we used g...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
سال: 2012
ISSN: 1874-9399
DOI: 10.1016/j.bbagrm.2012.01.019